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Furthermore, there was evidence for significant additional genetic factors specific to RTU and ND.
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Results: The results suggested that the liabilities to TI, RTU and ND were correlated.
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The variance specific to liability to RTU was entirely accounted for by additive genetic factors.
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QTu and RTu dispersion determined from the 12-lead ECG did not consistently reflect the myocardial changes.
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Conclusions: This study showed significant overlap in the contribution of genetic factors to individual differences in TI, RTU and ND.
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As the development of ND requires regular tobacco use (RTU) which in turn requires TI, a conditional approach is necessary.
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Method: We used structural equation modeling of multi-step conditional processes to examine the relationship between genetic and environmental risk factors for TI, RTU and ND.
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Over 80 % of the variance in liability to TI and RTU were shared, and a smaller proportion was shared between RTU and ND.